Tooth Regeneration: Turning Hopes into Realities

  • Kriti Garg Department of Conservative Dentistry and Endodontics, J.N. Kapoor DAV (C) Dental College, Yamuna Nagar, Haryana, India
  • Silky Mehta Department of Paedodontics and Preventive Dentistry, J.N. Kapoor DAV (C) Dental College, Yamuna Nagar, Haryana, India
  • C. V. Sruthi Vyaasini Department of Periodontics and Implantology, J.N. Kapoor DAV (C) Dental College, Yamuna Nagar, Haryana, India
  • Bhavika Sindhu Department of Paedodontics and Preventive Dentistry, Yamuna Institute of Dental Sciences, Gadholi, Yamuna Nagar, Haryana, India
  • Sheenam Kansal Department of Conservative Dentistry and Endodontics, JCD Dental College, Sirsa, Haryana, India
  • Roopali Sharma Dental Surgeon, Yamuna Nagar, Haryana, India
Keywords: Endodontics, Necrotic, Regeneration, Stem cell

Abstract

Functional tooth regeneration has shown promising therapeutic strategy. Tooth regeneration is possible by combine use of adult stem cells, growth factors, and scaffold. In recent years, researchers have explored tooth regeneration. Significant effort has been made in recent decades to identify and characterize tooth stem cells and to unravel the developmental programs which these cells follow to generate a tooth.

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References

Sharma S, Jindal L, Kumar A, Gaurav K, Munshi R, Anukriti. Die and die materials: An overview. Acta Sci Dent Sci 2020;4:22-8.

Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: New treatment protocol? J Endod 2004;30: 196-200.

Jindal L, Bhat N, Vyas D, Thakur K, Neha, Mehta S. Stem cells from human exfoliated deciduous teeth (SHED) turning useless into miracle: A review article. Acta Sci Dent Sci 2019;3:49-54.

American Association of Endodontists. Regenerative Endodontics Database. Chicago: American Association of Endodontists; 2003.

Gupta SS, Mahendra A. Gene therapy with growth factors for periodontal tissue engineering a review. J Med Oral Pathol Cirugia Bucal 2012;12:301-10.

Jindal L, Dua P, Mangla R, Gupta K, Vyas D, Bhat N. Stem cells the tiny procreators: A review article. Asian Pac J Health Sci 2019;6:118-23.

Prescott RS, Alsanes R, Fayad MI, Johnson BR, Wenckus CS. In vivogeneration of dental pulp like tissue by using dental pulp stem cells, a collagen scaffold and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod 2008;34:421-6.

Kim NR, Lee DH, Chung PH, Yang HC. Distinct differentiation properties of human dental pulp cells on collagen, gelatin and chitosan scaffolds. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:94-100.

Bazley LA, Gullick WJ. The epidermal growth factor receptor family. Endocr Relat Cancer 2005;12 Suppl 1:S17-27.

Martin I, Padera RF, Novakovic VG, Freed LE. In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone like tissues. J Orthop Res 1998;16:181-9.

Murray PE, Smith AJ. Saving pulps: A biological basis. An overview. Prim Dent Care 2002;9:21-6.

Murray PE, Godoy FG, Hargreaves KM. Regenerative endodontics: A review of current status and a call for action. J Endod 2007;33:377-90.

Stevens MM, Marini RP, Schaefer D, Aronson J, Langer R, Shastri VP. In vivo engineering of organs: The bone bioreactor. Proc Nat Acad Sci 2005;102:11450-5.

Hargreaves KM, Giesler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: What does the future hold? J Endod 2008;34:S51-6.

Shokouhinejad N, Alikhasi M, Bagheri P, Camilleri J. Prevention of coronal discoloration induced by regenerative endodontic treatment. Clin Oral Investig 2018;22:1725-31.

Lin LM, Kahler B. A review of regenerative endodontics: Current protocols and future directions. J Istanbul Univ Fac Dent 2017;51 Suppl 1:S41-51.

Kim JY, Xin X, Moioli EK, Chung J, Lee CH, Chen M. Regeneration of dental pulp like tissue by chemotaxis induced cell homing. Tiisu Eng Part A 2010;16:3023-31.

Chen SC, Chueh LH, Hsiao CK, Wu HP, Chiang CP. First untoward events and reasons for tooth extraction after nonsurgical endodontic treatment in Taiwan. J Endod 2008;34:671-4.

Ade SJ, Lins FF, Nagata JY, Gomes BP, Zaia AA, Ferraz CC, et al. Pulp revascularization after root canal decontamination with calcium hydroxide and 2% chlorhexidine gel. J Endod 2013;39:417-20.

Nagata JY, Gomes BP, Lima RT, Murakami LS, Faria FD, Campos GR, et al. Traumatized immature teeth treated with 2 protocols of pulp revascularization. J Endod 2014;40:606-12.

Iwaya SI, Iwaka M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol 2001;17:185-7.

Kontakiotis EG, Filippatos CG, Agrafioti A. Levels of evidence for the outcome of regenerative endodontic therapy. J Endod 2014;40:1045-53.

Saoud TM, Chen GM, Yen HM, Chen KL, Chen CA, Songtrakul K, et al. Treatment of mature permanent teeth with necrotic pulps and apical periodontitis using regenerative endodontic procedures: A case series. J Endod 2016;42:57-65.

Nevins AJ, Cymerman JJ. Revascularization of open apex teeth with apical periodontitis using a collagen-hydroxyapatite scaffold. J Endod 2015;41:966-73.

Saoud TM, Huang GT, Gibbs JL, Sigurdsson A, Lin LM. Management of teeth with persistent apical periodontitis after root canal using regenerative endodontic therapy. J Endod 2015;41:1743-8.

Anderson JO, Andreasen FM, Anderson J. Textbook and Color Atlas of Traumatic Injuries to the Teeth. 4th ed. Chichester, UK: Wiley Blackwell; 2017.

Tronstad L. Root resorption etiology, terminology and clinical manifestations. Endod dent Traumatol 1998;4:241-52.

Trope M. Root resorption due to dental trauma. Endod Top 2002;1:79-100.

Santiago CN, Pinto SS, Sassone LM, Hirata RJ, Fidel SR. Revascularization technique for the treatment of external inflammatory root resorption: A report of 3 cases. J Endod 2015;41:1560-4.

Priya H, Tambakad PB, Naidu J. Pulp and periodontal regeneration of an avulsed permanent mature incisor using platelet rich plasma after delayed replantation. A 12 month clinical case study. J Endod 2016;42:66-71.

Bhat N, Anjum R, Bhardwaj N, Thakur K, Nandan H. Stones within the dental pulp: Clinical Correlations. Int J Sci Res 2020;9:1-2.

Kim GS, Zhou J, Ye L, Cho S, Suzuki T, Fu SY, et al. Regenerative endodontics: Barriers and strategies for clinical translation. Dent Clin North Am 2012;56:639-49.

Iohara K, Zheng L, Ito M. Regeneration of dental pulp after pulpotomy by transplantaion of CD 31(-)/CD 146(-) side population cells from a canine tooth. Regen Med 2009;4:377-85.

Published
2020-08-05
How to Cite
Garg, K., Mehta, S., Sruthi Vyaasini, C. V., Sindhu, B., Kansal, S., & Sharma, R. (2020). Tooth Regeneration: Turning Hopes into Realities. Asian Pacific Journal of Health Sciences, 7(3), 30-34. https://doi.org/10.21276/apjhs.2020.7.3.8