Effect of Perioperative Intravenous Infusion of Lignocaine on Haemodynamic Responses to Intubation, Extubation and Post-Operative Analgesia

Authors

  • Dr. N. Trivikram Chalmeda Anandrao Institute Of Medical Sciences,Bommakal Village, Karimnagar , Telangana, India
  • A. Vishnuvardan Reddy Chalmeda Anandrao Institute Of Medical Sciences,Bommakal Village,Karimnagar, Telangana, India
  • Syed Ali Aasim Chalmeda Anandrao Institute Of Medical SciencesBommakal Village, Karimnagar ,Telangana ,India

DOI:

https://doi.org/10.21276/apjhs.2017.4.2.4

Keywords:

Analgesia, Extubation, Haemodynamics, Intubation, Lignocaine

Abstract

Background: Intravenous bolus dose of lignocaine is generally used to reduce haemodynamic changes associated with intubation and extubation. Whereas lignocaine intravenous infusion has been used for post‑ operative analgesia. Aims and Objectives: To evaluate the effect of peri-operative intravenous infusion of lignocaine on hemodynamic
responses to intubation, extubation and post-operative analgesia. Materials and Methods:80 patients undergoing elective laparoscopic cholecystectomy were included in our study and they were randomly divided into two groups, Group A and B of 40 each. Group A patients received 6 ml normal saline as bolus over 10 minutes followed by 6 ml/hour infusion, whereas in Group B, patients received preservative free 2% lignocaine 1.5 mg/kg IV bolus (made to a volume of 6 ml with normal saline) administered over a period of 10 minutes and thereafter an infusion at a rate of 1.5 mg/kg/hour (pre‑ diluted in normal saline made to a volume of 6 ml/hour. P < 0.05 was considered as significant. Results: Group B patients showed significantly longer mean pain‑ free post‑ operative period and also a less rise in pulse rate and mean arterial pressure compared to the Group A (P < 0.05) during intubation and extubation. Conclusion: Lignocaine infusion can successfully avert the change of haemodynamics resulting from intubation and extubation.

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Author Biographies

Dr. N. Trivikram, Chalmeda Anandrao Institute Of Medical Sciences,Bommakal Village, Karimnagar , Telangana, India

Post Graduate Student, Department Of Anesthesiology

A. Vishnuvardan Reddy, Chalmeda Anandrao Institute Of Medical Sciences,Bommakal Village,Karimnagar, Telangana, India

Assistant Professor, Department Of Anesthesiology

Syed Ali Aasim, Chalmeda Anandrao Institute Of Medical SciencesBommakal Village, Karimnagar ,Telangana ,India

Professor & HOD, Department Of Anesthesiology

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Published

2017-06-30

How to Cite

Dr. N. Trivikram, A. Vishnuvardan Reddy, & Syed Ali Aasim. (2017). Effect of Perioperative Intravenous Infusion of Lignocaine on Haemodynamic Responses to Intubation, Extubation and Post-Operative Analgesia. Asian Pacific Journal of Health Sciences, 4(2), 18–23. https://doi.org/10.21276/apjhs.2017.4.2.4