Distribution and susceptibility to various antifungal agents among blood stream Candida isolates from Neonatal intensive care unit

Authors

  • Dr. Deepak Kumar BHU Varanasi, India
  • Priyadarshini BHU Varanasi, India
  • Sriparna Basu BHU Varanasi, India
  • Ragini Tilak BHU Varanasi, India
  • Dhirendra Kumar BHU Varanasi, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.3.13

Keywords:

Candida, non albicans Candida, candidaemia, antifungal susceptibility, E test

Abstract

Background: During the past several decades, there has been a steady increase in the frequency of isolation of Candida spp. from blood stream infections from NICU worldwide. Furthermore, monitoring programs have detected an increase in the prevalence of infections caused by non albicans Candida (NAC). NAC are reported to be intrinsically resistant and less susceptible to empirically used azoles like Fluconazole. Thus speciation and antifungal susceptibility testing become imperative for these isolates. Objective: To study the trend in species distribution and antifungal susceptibility pattern among blood stream Candida strains isolated from neonatal intensive care patients was the aim of the study. Method: Susceptibility testing of clinically significant Candida isolates to various antifungal was performed by E-test in accordance with manufacturer instructions. The results obtained were analyzed and compared. Results: The most frequently isolated species was Candida tropicalis (52.83%) followed by Candida parapsilosis (16.98%), Candida albicans (9.4%), Candida glabrata (9.4%), Candida krusei (7.5%) and Candida guilliermondii (3.77%). Overall sensitivity of 85%, 81%, 26%, and 98% respectively to Amphotericin B, Fluconazole, Itraconazole and Voriconazole was found. Conclusion: The study shows the clinical significance and mycological shift of Candida species in blood culture of the neonatal population with a predominance of NAC species. Voriconazole showed an excellent activity and can be used in empirical treatment for candidemia rather than Fluconazole.

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Author Biographies

Dr. Deepak Kumar, BHU Varanasi, India

Assistant Professor, Department of Microbiology IMS

Priyadarshini, BHU Varanasi, India

Assistant Professor, Department of Microbiology IMS

Sriparna Basu, BHU Varanasi, India

Associate Professor Department of Paediatrics IMS 

Ragini Tilak, BHU Varanasi, India

Professor Department of Microbiology IMS 

Dhirendra Kumar, BHU Varanasi, India

Junior resident Doctor, Department of Microbiology IMS 

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Published

2018-09-30

How to Cite

Dr. Deepak Kumar, Priyadarshini, Sriparna Basu, Ragini Tilak, & Dhirendra Kumar. (2018). Distribution and susceptibility to various antifungal agents among blood stream Candida isolates from Neonatal intensive care unit. Asian Pacific Journal of Health Sciences, 5(3), 97–102. https://doi.org/10.21276/apjhs.2018.5.3.13