A Study on Estimation of plasma Fibrinogen and plasma fibrin degradation product (FDP) in women with preeclamptic pregnancy

Authors

  • D Sridhar Great Eastern Medical college and Hospital, Srikakulam, A.P., India
  • Kiranmai Great Eastern Medical college and Hospital, Srikakulam, A.P., India
  • Ch Ratnakaumar Great Eastern Medical college and Hospital, Srikakulam, A.P., India

DOI:

https://doi.org/10.21276/apjhs.2015.2.2s.11

Keywords:

Fibrin degradation products, fibrinogen, pre-eclampsia, pregnancy

Abstract

BACKGROUND: Preeclampsia is one of the commonest complications of pregnancy. It is associated with a state of hypercoagulability. The present study aimed to estimate the plasma fibrinogen and plasma FDP levels in preeclampsiaas compared to normal pregnancies. METHODS: This is a case-control hospital based study with normal pregnant women (n=36) and women with preeclampsia (n=64) in their third trimester were included in the study. Preeclamptic group was classified in to mild (n=42) and severe (n=22) preeclampsia. Plasma fibrinogen and FDP levels were analysed, and compared between the groups. RESULTS: Preeclampsia and normal pregnancy groups were comparable for age and body mass index but preeclampsia group had higher blood pressures and less period of gestation (p<0.0001). The levels of plasma fibrinogen (654.5±131.74 vs. 491.52±81.7 mg/dL) and plasma FDP (10.96±2.32 vs. 5.54±0.8 µg/L) were higher in the preeclampsia group as compared to normal pregnancy (p<0.0001). Elevations in fibrinogen and FDP levels were more marked for severe preeclampsia group than mild preeclampsia group.CONCLUSION: Preeclampsia is associated with high fibrinogen and FDP levels as compared to normal pregnancies. Severe preeclampsia patients have greater elevations as compared to mild preeclampsia patients.

Downloads

Download data is not yet available.

Author Biographies

D Sridhar, Great Eastern Medical college and Hospital, Srikakulam, A.P., India

Department of OBG, 

Kiranmai, Great Eastern Medical college and Hospital, Srikakulam, A.P., India

Department of Biochemistry, 

Ch Ratnakaumar, Great Eastern Medical college and Hospital, Srikakulam, A.P., India

Department of Biochemistry, 

Downloads

Published

2015-12-31

How to Cite

D Sridhar, Kiranmai, & Ch Ratnakaumar. (2015). A Study on Estimation of plasma Fibrinogen and plasma fibrin degradation product (FDP) in women with preeclamptic pregnancy. Asian Pacific Journal of Health Sciences, 2(4(s), 60–63. https://doi.org/10.21276/apjhs.2015.2.2s.11