@article{Dr.Niladri Deb_Deepika Lahon_Pradeep Sharma_2016, title={A study on probable correlation of AST/ALT (De Ritis) ratio with the advancement of underlying severity of alcoholic liver disease in the North East Indian population }, volume={3}, url={https://apjhs.com/index.php/apjhs/article/view/614}, DOI={10.21276/apjhs.2016.3.2.2}, abstractNote={<p>Background: Alcohol consumption has been linked with one of the most common causes of liver disease, and the AST/ALT (De Ritis) ratio has emerged as a useful indicator for its diagnosis. Our study is on patients of alcoholic liver disease, graded as per Child-Pugh classification, and an effort was made to examine whether AST/ALT ratio can indicate the underlying severity of liver damage caused by alcohol abuse.<br>Materials and methods: A sample of 142 patients of alcoholic liver disease undergoing treatment in Satribari<br>Christian Hospital, Guwahati, India from December 2014 to February 2016 was selected for the study. Blood samples were collected and AST/ALT ratio and Child-Pugh score of all the patients were calculated from the biochemical and clinical parameters.<br>Results: The mean age of the subjects was 49 years and there were more males (97.89%) than female patients, who were diagnosed with alcoholic liver disease. Using Child-Pugh score, subjects were grouped into A, B and C. Estimation of AST/ALT ratio shows that the mean values of the ratio were 1.7350, 2.0751 and 2.7608 respectively for A, B and C classes and there exists statistical difference among mean values of the ratio across class groups. Further, this study highlights that there exist a positive correlation (r= 0.362 & p=0.000) between Child-Pugh score and the AST/ALT ratio. In fact, this was found to be statistically significant. Conclusion: On the basis of results obtained, it can be said that the value of AST/ALT ratio has a positive correlation with the advancement of the underlying liver damage.</p>}, number={2}, journal={Asian Pacific Journal of Health Sciences}, author={Dr.Niladri Deb and Deepika Lahon and Pradeep Sharma}, year={2016}, month={Jun.}, pages={5–10} }