TY - JOUR AU - Said Kaddouri, AU - Hassan Qacif, AU - Zakaria Chahbi, AU - Zemraoui Nadir, AU - Mohamed Zyani, PY - 2017/12/30 Y2 - 2024/03/28 TI - Tubulointerstitial nephritis and uveitis syndrome: A case series JF - Asian Pacific Journal of Health Sciences JA - APJHS VL - 4 IS - 4 SE - Table of Contents DO - 10.21276/apjhs.2017.4.4.3 UR - https://apjhs.com/index.php/apjhs/article/view/15 SP - 9-11 AB - <p>The tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) affects adolescent females preferentially, and it is typically<br>characterized by the association of tubulointerstitial nephritis and anterior bilateral uveitis. However, it may have different atypical<br>presentations. It can be seen in male, in adults, without renal insufficiency, or with a posterior uveitis. We report three cases of<br>atypical TINU syndrome. We reported two out of three adult patients (16, 60, and 62 years of age), two of whom were female and<br>one male. The first patient had a panuvéitis of the left eye and a posterior uveitis of the right eye. The second patient presented<br>bilateral panuveitis with retinal vasculitis. The third patient had a bilateral anterior uveitis recurrent. The three patients had<br>proteinuria, glucosuria, aseptic leukocyturia without renal insufficiency. Renal biopsy showed tubulointerstitial nephritis with<br>no sign of vasculitis or glomerular involvement. The etiological investigation did not find any cause (infection, medication, and<br>systemic illness). The patients received a local and general corticosteroid therapy associated in one case with methotrexate, which<br>has resulted in rapid improvement for all three patients. This clinical case report highlights some important features of TINU<br>syndrome, including the increasing incidence of disease in male and adult patients, the possibility of a posterior involvement of<br>uveitis, and clinical presentation without kidney failure. Extensive studies are needed to elucidate the cause and pathogenesis of<br>this syndrome for better management.</p><p>&nbsp;</p> ER -