TY - JOUR AU - Prabhjot Singh Bajwa, AU - Jaya Sharma, AU - Anurag Bhargava, AU - Shailesh Sharma, AU - Abhimanyu Rai Sharma, AU - Binu Raina, PY - 2018/03/30 Y2 - 2024/03/28 TI - Design and development of immediate release tablets of terbutaline sulfate using 32 full factorial statistical design JF - Asian Pacific Journal of Health Sciences JA - APJHS VL - 5 IS - 1 SE - Table of Contents DO - 10.21276/apjhs.2018.5.1.11 UR - https://apjhs.com/index.php/apjhs/article/view/37 SP - 47-52 AB - <p>Aim: Present study was aimed at developing an immediate release tablets (IRT) of Terbutaline sulphate (TS) that can be used forquick relief from asthma attacks.<br>Method: IRT’s were formulated using Ac-Di-Sol and Sodium starch glycolate as superdisintegrants. There concentrations were optimized using a 32 full-factorial design to produce tablets able to disintegrate within 30 s with minimum friability. Then the tablets were evaluated for physical evaluation and drug release studies.<br>Results: The optimizedIRT formulation (OIRT1) showed a disintegration time of 31.67 ± 0.577 s and friability value of 0.58 ± 0.021 %. The accelerated stability studies showed no significant changes in physicochemical properties and release behaviour.<br>Conclusions: It can be concluded from the study that the IRT of TS can be successfully formulated to get a fast release and these tablets can be used to get quick relief from asthma attacks.</p> ER -