TY - JOUR AU - Aniruddh Dev Singh, AU - Sushil Kumar, AU - Sarika Saini, AU - Harsh Prabha, PY - 2017/12/30 Y2 - 2024/03/28 TI - Synthesis and biological evaluation some new of 7-hydroxy-4-methylcoumarin derivative JF - Asian Pacific Journal of Health Sciences JA - APJHS VL - 4 IS - 4 SE - Table of Contents DO - 10.21276/apjhs.2017.4.4.21 UR - https://apjhs.com/index.php/apjhs/article/view/75 SP - 84-93 AB - <p>7-hydroxy-4-methylcoumarin derivatives were synthesized. The title compounds (M1-M5) were obtained by the reaction of<br>7-hydroxy-4-methylcoumarin with ethyl chloroacetate in the presence of potassium carbonate in acetone afforded ethyl-2-<br>(4-methyl-2-oxo-2H-chromen-7-yloxy)acetate, which react with hydrazine hydrate in ethanol afforded 2-(4-methyl-2-oxo2H-chromen-7-yloxy) acetohydrazide, on further reaction with various acetophenones in the presence of glacial acetic acid<br>in absolute alcohol gave 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N’-substituted acetohydrazides (M1-M5). The structures of<br>target compounds (M1-M5) were established on the basis of infrared and 1<br>H-nuclear magnetic resonance spectral analysis. Target<br>compounds (M1-M5) were screened for their antimicrobial activity and showing significant antimicrobial activity as compared<br>to standard drug.<br><br></p> ER -