Study of Efficacy and Safety of Injection Depot Medroxy Progesterone Acetate In Lactating and Non-lactating Women

Abstract

Subject: This was a prospective study of efficacy and safety of injection depot medroxy progesterone acetate (DMPA) in lactating and non-lactating women. Abstract: The population of India is growing rapidly. The socio-economic problem of overpopulation is too well known. The use of safe and effective contraception is the need of the hour in India. Contraceptive advice is a vital component of good community health. Aims and Objective: The present study aims to study the establish safety and effectiveness of injection DMPA as a contraceptive method, acceptance, and continuation rate of injection DMPA in lactating mothers who had received first dose at postpartum period and non-lactating women and study the side effect of injection DMPA. Methods: A prospective study was conducted, at J K Lone mother and Child Hospital, Government Medical College Kota, Rajasthan, between April 2019 and April 2020. One hundred women were given injection DMPA 150 mg intramuscularly taken as study group and 100 women not using hormonal contraception were taken as controls group. They were followed at every 3 months. The comparison between the two groups was done using student t-test Chi-square test for calculation of p value. Results: The study was conducted to evaluate that women who were used DMPA mean age were 25.35 years. Overall accepted rate is 20%. No effect of literacy on acceptance rate. Significant menstrual irregularity found which was most common reason for attrition. Failure rate was zero among DMPA user. No significant effect on BP, blood sugar, and weight gain. No adverse effect on lactation. Conclusion: The study concludes that DMPA is a very effective contraceptive. Women accept it very easily without much degree of motivation. However, side effect decreases compliance.