Design and Development of Dual Drug Loaded Niosomes Containing Amoxicillin and Clavulanic acid

Authors

  • B Kumar Sunrise University, Alwar,Rajasthan, India
  • G. Jeyabalan Sunrise University, Alwar, Rajasthan, India

DOI:

https://doi.org/10.21276/apjhs.2017.4.2.33

Keywords:

Niosomes, drug, amoxicillin, clavulanic acid

Abstract

Niosomes formulation for the fixed dose combinations of amoxicillin-clavulanic acid were prepared using Span 60 and cholesterol by the ether injection method. Span 60 and cholesterol were added in various molar ratios to affect the vesicle membrane rigidity. Drugs combinations of amoxicillin-clavulanic acid entrapped in the bilayer of niosomes were quantified and the entrapment efficiency was found to be reaching up to 76%. The size and size distribution of niosomes were determined on light microscopy and transmission electron microscopy. The accelerated stability testing was used to predict the stability of the formulations. The test revealed changes in the characteristics of the liposomes. The in-vitro antibacterial assay of amoxicillin-clavulanic acid, revealed that niosomes formulations have stronger inhibitory activity.

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Author Biographies

B Kumar, Sunrise University, Alwar,Rajasthan, India

Department of Pharmacy

G. Jeyabalan, Sunrise University, Alwar, Rajasthan, India

Department of Pharmacy

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Published

2017-06-30

How to Cite

B Kumar, & G. Jeyabalan. (2017). Design and Development of Dual Drug Loaded Niosomes Containing Amoxicillin and Clavulanic acid. Asian Pacific Journal of Health Sciences, 4(2), 206–213. https://doi.org/10.21276/apjhs.2017.4.2.33

Issue

Vol. 4 No. 2 (2017): Vol 4 | Issue 2 | April - June 2017

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.