The Role of Probiotics in Alzheimer’s Disease
Keywords:Alzheimer’s disease, Amyloid precursor protein, Brain-derived neurotrophic factors, Central nervous system, Neurofibrillary tangles, Short-chain fatty acids.
Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease that starts slowly and gradually worsens over the time and further leads to cognitive impairment and causes dementia. Since it is the most common neurodegenerative disease in older adults, no successful treatment has been reported. However, many studies in AD are associated with gut microbial alterations. Probiotics are living microorganisms that provide health benefits when consumed in the proper amount. Some probiotic strains provide health benefits such as improving the intestinal environment, immunomodulatory functions, prevention of infections, anti-obesity effects, cancer-preventing effects, and extension of life span.
In contrast, some probiotic strains ameliorate cognitive impairment, CNS behavior, and depressive disorder. In many studies, probiotics have shown preventive and therapeutic potential in the case of AD. This review article aims to give a complete analysis of the role of probiotics in AD symptoms.
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Copyright (c) 2022 Siddharth S. Thakur, Navneet Khurana, Neha Sharma, Neha Sharma
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