Antinociceptive and Anti-Inflammatory Activity of Beta-Sitosterol

Authors

  • Lakshminarayanan Arivarasu Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India, Department of Pharmacology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.
  • Valli Gunam Department of Pharmacology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.21276/apjhs.2022.9.2.06

Keywords:

Analgesia, Ibuprofen, Morphine, Nociceptive, Paracetamol, β-sitosterol

Abstract

Background: Phytosterols are commonly present in various plants, among which sitosterol is the abundant one. Various extracts of leaves of the plant were screened but a purified phytosterol like β-sitosterol (BS) is a compound of interest. Objective: The aim of the study is to evaluate for analgesic and anti-nociceptive property of activity BS. Materials and Methods: Hot plate test and Acetic acid-induced writhing’s test was used for evaluating the central and peripheral Antinociceptive activity and Anti-inflammatory activity was evaluated by carrageenan-induced hind paw edema method. Results: BS (10 and 20 mg/kg, i.p.) was responsible for the significant and dose-dependent activity comparable with the standard. Conclusion: The dose dependent activity of β-sitosterol might be responsible for analgesic and anti-inflammatory activity, this may also be a vital observation for further studies.

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Published

2022-04-01

How to Cite

Lakshminarayanan Arivarasu, & Valli Gunam. (2022). Antinociceptive and Anti-Inflammatory Activity of Beta-Sitosterol. Asian Pacific Journal of Health Sciences, 9(2), 26–28. https://doi.org/10.21276/apjhs.2022.9.2.06

Issue

Vol. 9 No. 2 (2022): Vol 9 | Issue 2 | April - June 2022

Section

Articles

License

Copyright (c) 2022 Lakshminarayanan Arivarasu, Valli Gunam

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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