Assessment of Protein Oxidation Status and Its Correlation with Antioxidant Potential in Preeclampsia

Authors

  • Jigeesha Mishra Department of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bioengineering, SHUATS, Prayagraj, Uttar Pradesh, India,
  • Kanti Bhooshan Pandey CSIR-CSMCRI, Gijubhai Badheka Marg, Bhavnagar, Gujarat, India
  • Shailendra Kumar Srivastava Department of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bioengineering, SHUATS, Prayagraj, Uttar Pradesh, India,

DOI:

https://doi.org/10.21276/apjhs.2022.9.2.45

Keywords:

Biomarkers, Oxidative stress, Preeclampsia, Protein oxidation

Abstract

Objective: The objective of the study is to assess protein oxidation status and its correlation with antioxidant potential in serum during preeclampsia (PE). Materials and Methods: A casecontrol study was performed on 63 pregnant subjects (mean age = 30 tential in serpreeclamptic and 32 age-matched normotensive (control) pregnant women. Serum samples were analyzed for total protein, globulin, albumin, protein carbonyls (PCO), advanced oxidation protein products (AOPP), and ferric reducing antioxidant potential. Results: Compared to the control pregnant subjects, a compromised serum protein pattern, elevated PCO (P < 0.01), and AOPP (P < 0.02) were observed in PE pregnant women that were correlated significantly with the total antioxidant potential of serum. Conclusion: The results of the study suggest that PE pregnancies are susceptible to protein oxidation which may be due to diminished antioxidant potential during PE. The study concludes that oxidative modulation of proteins may be one of the major causative factors in complicating the maternal and fetal conditions during PE.

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Published

2022-04-01

How to Cite

Jigeesha Mishra, Kanti Bhooshan Pandey, & Shailendra Kumar Srivastava. (2022). Assessment of Protein Oxidation Status and Its Correlation with Antioxidant Potential in Preeclampsia. Asian Pacific Journal of Health Sciences, 9(2), 226–229. https://doi.org/10.21276/apjhs.2022.9.2.45

Issue

Vol. 9 No. 2 (2022): Vol 9 | Issue 2 | April - June 2022

Section

Articles

License

Copyright (c) 2022 Jigeesha Mishra, Kanti Bhooshan Pandey, Shailendra Kumar Srivastava

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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