A mini review on solubility enhancement technique – Solid dispersion

Abstract

Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. Generally, SDs can be defined as a dispersion of active ingredients in molecular, amorphous and/or microcrystalline forms into an inert carrier. The application of solid dispersions is a useful method to increase the dissolution rate of drugs. This article is indented to combine literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods and evaluation parameters.