Design and Biological Evaluation of Novel Arylidene Hydrazides Derivatives for Anticonvulsant Activity

Abstract

The aim of present study was to design and synthesized a novel series of compound which can be evaluate for anticonvulsant, anti-microbial activity. This novel derivatives of Arylidene Hydrazides (4a-4k) were synthesised from o-chloro benzoic acid and aniline via Ulmann reaction. The synthetic method used was simple, rapid and economical found to be accurate and reproducible. The series of chemical reaction was yielded as 11 novel Arylidiene Hydrazide according to the scheme. The chemical structures of the synthesized molecules were confirmed by different lab as well as instrumental analysis like TLC, IR, NMR, and MS. All the synthesised compounds were evaluated for anticonvulsant activity by using two different models on Wistar albino rats. The most common model for anticonvulsant activities are maximal electroshock seizure and subcutaneous pentylenetetrazole (scPTZ) which we were applied for the same. The title compounds 4a & 4b exhibited anticonvulsant potency against all the two screens methods with actuate toxicity. After completion of experiments the SAR of molecule suggest that it must be have site as hydrophobic aryl ring system, (HBD) hydrogen binding domain, (D) electron donor moiety, (C) distal aryl ring.