Stereochemistry of Dihydropyrimidinones Derivatives Synthesized by Brick Dust Catalytic Reaction

Authors

  • Divya Chauhan Department of Pharmaceutical Chemistry, Lovely Professional University, Phagwara, Punjab, India.
  • Surendra Kumar Nayak Department of Pharmaceutical Chemistry, Lovely Professional University, Phagwara, Punjab, India.
  • Sanjeev Kumar Sahu Department of Pharmaceutical Chemistry, Lovely Professional University, Phagwara, Punjab, India.

DOI:

https://doi.org/10.21276/apjhs.2022.9.2.56

Keywords:

Biginelli reaction, Brick dust, Stereochemistry

Abstract

A number of catalytic synthetic reactions have been reported which play the important role in stereochemistry of compounds. The key to the success of this protocol was the generation of stereogenic centers in 1, 4-Dihydropyrimidinones (DHPMs) and the influence of catalysts on their configuration. Waste brick dust was found to be an effective catalyst, generating chiral DHPMs derivatives using aryl aldehyde, urea, and ethyl acetoacetate. This work mainly focuses on the stereochemistry of brick-dust catalyzed DHPMs derivatives. Discovery of brick dust catalyst associated with several benefits such as rapid clean reaction, simple, and ease work-up.

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Published

2022-04-01

How to Cite

Divya Chauhan, Surendra Kumar Nayak, & Sanjeev Kumar Sahu. (2022). Stereochemistry of Dihydropyrimidinones Derivatives Synthesized by Brick Dust Catalytic Reaction. Asian Pacific Journal of Health Sciences, 9(2), 283–287. https://doi.org/10.21276/apjhs.2022.9.2.56

Issue

Vol. 9 No. 2 (2022): Vol 9 | Issue 2 | April - June 2022

Section

Articles

License

Copyright (c) 2022 Divya Chauhan, Surendra Kumar Nayak, Sanjeev Kumar Sahu

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.