Proniosome-Based Transdermal Drug Delivery of Resveratrol

Authors

  • Bhawana Sharma Department of Pharmaceutics, Bhupal Nobles University, Udaipur, Rajasthan, India.
  • Amul Mishra Department of Pharmaceutics, Bhupal Nobles University, Udaipur, Rajasthan, India.
  • Piush Sharma Department of Pharmacy, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, India.
  • Shiv Garg Department of Pharmacy, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, India.
  • Abhishek Dwivedi Department of Pharmacy, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, India.
  • Savita Rathor Department of Pharmacy, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, India.

DOI:

https://doi.org/10.21276/apjhs.2023.10.2.13

Keywords:

Permeation, Proniosomes, Resveratrol, Transdermal drug delivery

Abstract

Vesicular systems have been receiving a lot of interest as a carrier for advanced drug delivery. The present investigation aimed at the development and characterization of proniosome based transdermal delivery of resveratrol. The proniosomal structure was a liquid crystalline-compact niosomes hybrid which could be converted into niosomes upon hydration by skin itself. To optimize the formulation, various proniosomes composed of various ratios of sorbitan fatty acid esters, polysorbates, cholesterol, and lecithin were prepared by the coacervation-phase separation method. From each of the prepared proniosomes, the entrapment efficiency with span 60 was found to be the highest. The effects of cholesterol, phospholipids, and solvents were also assessed. Optimized formulation was characterized for entrapment efficiency, scanning electron microscope, transmission electron microscope, in vitro release study, vesicle size, and stability studies at 4°C and room temperature. Thus, proniosome was found to be a promising carrier system for resveratrol because of ease of preparation and better bioavailability.

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Published

2023-08-11

How to Cite

Bhawana Sharma, Amul Mishra, Piush Sharma, Shiv Garg, Abhishek Dwivedi, & Savita Rathor. (2023). Proniosome-Based Transdermal Drug Delivery of Resveratrol. Asian Pacific Journal of Health Sciences, 10(2), 55–62. https://doi.org/10.21276/apjhs.2023.10.2.13

Issue

Vol. 10 No. 2 (2023): Vol 10 | Issue 2| April - June 2023

Section

Articles

License

Copyright (c) 2023 Bhawana Sharma, Amul Mishra, Piush Sharma, Shiv Garg, Abhishek Dwivedi, Savita Rathor

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.