Unconventional Biomarkers: Early ‘Snapshots’ of Cardiovascular risk in Young Overweight and Obese adults
Keywords:Coronary artery disease, Waist:Hip circumference, monocyte, Uric acid, lymphocyte, neutrophil
Background:Atherosclerosis of the coronary arteries leads to a restriction in coronary blood flow. Multiple studies have demonstrated that total leukocyte, monocyte and neutrophil counts are significantly higher in CAD patients. Serum uric acidhas also been found to be an independent risk factor for both cardiovascular and renal diseases.Looking at the dearth of data regarding association of these risk markers in overweight and obese young adults, this study was carried out.Aim and Objectives: To study the correlation of pro-inflammatory markers of development of coronary artery disease in overweight and obese young adults.Methodology: A prospective crosssectional study was conducted in a rural Tertiary Care centre for a period of two months.Two hundred medical students acted as study participants, and were subdivided into healthy controls, and an overweight/obese group. Anthropometric data, haematological, and biochemical parameters were obtained, and correlated with respective groups.Statistical Analysis:Chi square test and Student ‗t‘ Test were employed, with software used for the analysis being IBM SPSS Version 22.0, and p <0.05 being considered as significant.Results:Waist circumference and waist hip ratio (WHR) was significantly more in overweight and obese adults suggesting increased prevalence of visceral obesity. The monocyte percentage, neutrophil to lymphocyte ratio (NLR), and Serum uric acid levels were significantly elevated in overweight/obese category (p<0.05). Conclusion:The study demonstrated that overweight and obese young adults do have significantly increased levels of some unconventional biomarkers which can indicate future risk of cardiovascular diseases, and thus are indeed early ―snapshots‖ which can be considered as warning signs. Early lifestyle modificationcan reduce the risk of cardiovascular disorders in such individuals.
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