Effect of Ipomoea staphylina leaves on Streptozotocin- Nicotinamide Induced Type-II Diabetes in Wistar Rats

Authors

  • S M Firdous NIMS University, Shobha Nagar, Jaipur-Delhi Highway (NH-11C),Jaipur- 303121, Rajasthan, India
  • Anoop Singh NIMS University, Shobha Nagar, Jaipur-Delhi Highway (NH-11C),Jaipur- 303121, Rajasthan, India

DOI:

https://doi.org/10.21276/apjhs.2016.3.3.6

Keywords:

Antidiabetic, Ipomoea staphylina (IS), streptozotocin (STZ), nicotinamide, body weight, blood glucose, total cholesterol, triglycerides, creatinine

Abstract

The aim of the present study was to evaluate the antidiabetic activity of Ipomoea staphylina (IS) leaves in Streptozotocin (STZ)-nicotinamide induced type-II diabetic in rats. Oral administration of ethanolic extract of IS leaves and its fractions at the doses of 100 mg/kg and 200 mg/kg was studied in glucose-loaded and STZnicotinamide induced diabetic rats. The effects of extract and its fractions on blood glucose, body weight, lipid profile, plasma enzymes (SGOT, SGPT and ALP), serum urea, creatinine, total protein, liver glycogen, and activities of SOD, CAT and GPx in diabetic rats were analyzed. The IS extract and its fractions significantly reduced the blood glucose level in glucose-loaded rats. After treatment with IS extract and its fractions (100 and 200 mg/kg) for 21 days there was a significant decrease in blood glucose, total cholesterol, triglycerides, LDL-C, VLDL-C, plasma enzymes (SGOT, SGPT and ALP), serum urea, creatinine and significant increase in body weight and total protein levels was observed in treated diabetic rats. The activities of antioxidant enzymes SOD, CAT and GPx were also inceased in diabetic mice after the treatment with IS extract and its fractions. Histological analysis showed improvement in the cellular architecture of pancreas, liver and kidney.

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Author Biographies

S M Firdous, NIMS University, Shobha Nagar, Jaipur-Delhi Highway (NH-11C),Jaipur- 303121, Rajasthan, India

Department of Pharmaceutical Science, 

Anoop Singh, NIMS University, Shobha Nagar, Jaipur-Delhi Highway (NH-11C),Jaipur- 303121, Rajasthan, India

Department of Pharmaceutical Science, 

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Published

2016-09-30

How to Cite

S M Firdous, & Anoop Singh. (2016). Effect of Ipomoea staphylina leaves on Streptozotocin- Nicotinamide Induced Type-II Diabetes in Wistar Rats. Asian Pacific Journal of Health Sciences, 3(3), 30–44. https://doi.org/10.21276/apjhs.2016.3.3.6

Issue

Vol. 3 No. 3 (2016): Vol 3 | Issue 3 | July - September 2016

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.