Study of Morphological Features of Carcinoma of Breast in Relation to ER/PR and Her2/neu Status
Keywords:Breast carcinoma, Immunohistochemistry, Morphology and Triple markers
Introduction: A steep rise in breast cancer cases is anticipated over the coming years in India. Breast cancer in India, is the most common cancer among women in the urban areas and ranks second in the rural population. Aims: To study the morphological features of breast carcinoma, to identify hormone receptor status and to study the relation between morphological features and hormone receptor status. Materials and Methods: This was a retrospective and prospective study carried out over a period of two years. A total of 100 cases of carcinoma breast were studied for morphological features and their relation to hormone receptor status. Results: The mean age at presentation was 50 years and was more common in postmenopausal women, (70 %) cases. Right breast, especially the upper outer quadrant was most frequently involved. (52% cases). Most common size of tumor ranged between 2 to 5cm. Most common histological type of breast carcinoma was invasive ductal carcinoma NOS (not otherwise specified) (83.2%). Both premenopausal and postmenopausal cases showed triple negative as the most common pattern. Among the invasive ductal carcinoma cases, triple negative was the most common pattern. Most common tumor grade in the present study group was grade II and triple negative was the most common pattern in this group. Well defined lypmhovascular emboli were present in 16 %, tumor necrosis in 53% of cases and desmoplasia in 60% of cases. Only 16% of cases showed infiltration of basal cut margin. Conclusion: Breast cancer cases diagnosed at an earlier stage have more favorable prognosis. Increasing the awareness in the public and good programs for early detection of the disease will go a long way in reducing breast cancer.
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