Aqueous extract of Geniosporum prostratum (L)Benth plant and its role in reducing oxidative stress in STZinduced diabetic rats

Authors

  • Ashutosh Upadhayay NIMS University, Shobhanagar, Jaipur, Rajasthan, India
  • ASHISH SHARMA NIMS University, Shobhanagar, Jaipur, Rajasthan, India
  • N. THIRUMURTH Cherraan’s College of Pharmacy, Coimbatore - 641 035.(T.N.), India

DOI:

https://doi.org/10.21276/apjhs.2016.3.4.4

Keywords:

Catalase, Geniosporum prostratum, Glutathione, Lipid peroxidase, Oxidative stress, Superoxidedismutase

Abstract

To evaluate aqueous extract of Geniosporum prostratum (L) Beanth in normal and streptozotocin (STZ) induced diabetic rats. Diabetes was induced by intraperitoneally (i.p) streptozotocin (60mg/kg)adult male albino wister rats (8 weeks), weighing 200 to 250 g. Blood glucose levels were determined after oral administration of G. Prostratum (200 mg/kg) in diabetic groups. At the end of 21 daysafter daily oraladministration of aqueous extract of G.
Prostratum(100 &200 mg/kg) and standard drug (600 μg/kg) in diabetic rats, rats were autopsized and liver was removed. The effect of extracts of G. Prostratumon antioxidant like catalase, superoxide dismutase, lipid peroxidase and glutathione were estimated in the diabetic and non-diabetic rats. There was significant increase in catalase, superoxide dismutase, liver peroxidase and glutathione in extracts treated diabetic rats. These results indicate that G. Prostratumreduce anoxidative stress in diabetic rats.

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Author Biographies

Ashutosh Upadhayay, NIMS University, Shobhanagar, Jaipur, Rajasthan, India

Department of Pharmaceutical Science

ASHISH SHARMA, NIMS University, Shobhanagar, Jaipur, Rajasthan, India

Department of Pharmaceutical Science 

N. THIRUMURTH, Cherraan’s College of Pharmacy, Coimbatore - 641 035.(T.N.), India

Professor & HOD, Department of Pharmaceutics

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Published

2016-12-30

How to Cite

Ashutosh Upadhayay, ASHISH SHARMA, & N. THIRUMURTH. (2016). Aqueous extract of Geniosporum prostratum (L)Benth plant and its role in reducing oxidative stress in STZinduced diabetic rats. Asian Pacific Journal of Health Sciences, 3(4), 23–29. https://doi.org/10.21276/apjhs.2016.3.4.4

Issue

Vol. 3 No. 4 (2016): Vol 3 | Issue 4 | October - December 2016

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.