Synthesis and evaluation of some 2-((benzothiazol-2-ylthio) methyl)-5-phenyl-1, 3, 4- oxadiazole derivatives as antidiabetic agents

Authors

  • Dr. Sunil Kumar NIMS Institute of Pharmacy, NIMS University, Jaipur(Rajasthan) India
  • D S Rathore NIMS Institute of Pharmacy, NIMS University, Jaipur(Rajasthan) India
  • Gopal Garg NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan) India
  • Rahul Saxena NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan) India
  • Kapil Khatri Ravishankar College of Pharmacy, Bhopal (M.P.) India
  • Sanjeev K. Sahu Oriental College of Pharmacy, Bhopal (M.P.) India

DOI:

https://doi.org/10.21276/apjhs.2016.3.4.10

Keywords:

Diabetes, Substituted benzthiazole derivatives, Oxadiazole, Hypoglycemic activity, Alloxan induceddiabetic model

Abstract

Some of derivatives containing oxadiazole and benzothiazole moieties 6(a-l) were synthesized and the structure of synthesized compounds was elucidated by IR, 1HNMR, 13C NMR and mass spectroscopy. This research article deals with newly synthesized benzothiazole containing oxadiazole derivatives that were assayed for investigation of their in vivo hypoglycemic activity by alloxan induced diabetic model in rat. All these derivatives showed significant biological efficacy when compared to a potent and well known antidiabetic agent (i.e. Glibenclamide). All the compounds were effective, amongst them 6f showed more prominent activity at 350 mg/kg p.o. The experimental results are statistically significant at p<0.01 and p<0.05 level.

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Published

2016-12-30

How to Cite

Dr. Sunil Kumar, D S Rathore, Gopal Garg, Rahul Saxena, Kapil Khatri, & Sanjeev K. Sahu. (2016). Synthesis and evaluation of some 2-((benzothiazol-2-ylthio) methyl)-5-phenyl-1, 3, 4- oxadiazole derivatives as antidiabetic agents. Asian Pacific Journal of Health Sciences, 3(4), 65–74. https://doi.org/10.21276/apjhs.2016.3.4.10

Issue

Vol. 3 No. 4 (2016): Vol 3 | Issue 4 | October - December 2016

Section

Table of Contents

License

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