Gastroretentive drug delivery system: an overview
Keywords:Approaches of GRDDS, Evaluation parameters, Gastro-retentive drug delivery system, probablepolymers used in GRDDS, recent patents on GRDDS
Gastric emptying is a complex process and makes the in vivo performance of the drug delivery system uncertain. In order to avoid this fickleness, efforts have been made to increase the retention time of the dosage form, that is the development to gastroretentive drug delivery system. Gastroretentive drug delivery system (GRDDS) can remain in the stomach for prolonged period of time and there by increases gastric residence time of drugs, and also improves the bioavailability of certain drugs. These are widely used for the site specific drug delivery, for the treatment of gastrointestinal diseases and disorders. There are several approaches of Gastroretentive drug delivery system which are discussed in detail in the present review. Recent patents on (GRDDS) are also enlisted with a detailed description of evaluation parameters of the same.
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