Preparation and Evaluation of Ketoprofen-loaded Sodium Alginate Beads
Keywords:Anti-inflammatory, Ketoprofen, alginate beads, ionotropic gelation
Ionotropic gelation was used to entrap Ketoprofen in sodium alginate beads. Ketoprofen is NSAIDs category drug; it has a short half life (1.5-2 h) and side effects such as irritation and ulceration in GIT. Beads were characterized for possible sustained drug release .On the basis of differential scanning colorimetry and IR spectroscopy, XRD alginate were found to be compatible with Ketoprofen. SEM showed that the beads were spherical and small. Ketoprofen encapsulation efficiencies were high (>90%), also results showed that, release profile in 0.1M HCl (pH 1) was slow. In phosphate buffer complete drug release was shown for all formulations within 6 h. The mechanism of release depended on swelling of beads. The swelling behavior dependent on pH of the medium; such a pH sensitive swelling could be auspicious for orally administered drug vehicles especially for acid sensitive drugs.
How to Cite
Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.