Study of comparison of obtaining transcervical chorionic villus sampling by needle and infant feeding tube

Abstract

The developmental abnormalities are on rise, due to increased exposure to environmental toxins and intervention in reproductive process and so the risk to any pregnant couple of having up to 5% live-born infant with a chromosomal abnormality or structural defect had been estimated to be 3–5%. Thus, the need of diagnostic means to do early maternal screening at peripheral centers is also required to identify at-risk pregnancies in more accurate and faster way. Of all different ways available amniocentesis and chorionic villus biopsy are te for congenital defects are most accurate and definitive but carry significant risk of fetal loss. Chorionic villus sampling done under ultrasound guidance decreases this risk and increases the accuracy of procedure. This study was done few years back as part of thesis in Maulana Azad Medical College along with Gynaecology and Obstetrics Department of LNJP Hospital. In this study, transcervical sampling of chorionic tissue was done under ultrasound guidance in females undergoing medical termination of pregnancy in the first trimester, and tissue was procured with chorionic villus sampling (CVS) biopsy needle and then with infant feeding tube. Both obtained tissues were proceeded in the same way and same environment. Of 20 samples done, 18 samples were successfully obtained by infant feeding tube, and of this, 16 samples were adequate to be processed. While with biopsy needle, tissues were obtained in all but adequate tissue obtained in 18 only. Thus, sampling by infant feeding tube is an cost-effective method to procure chorionic villus at peripheral centers too for screening and diagnosing genetic diseases, thus decreasing load on referral centres.