Clinicoimmunological Study of Autoimmune Hepatitis
Keywords:Autoimmune hepatitis, autoimmune liver disease, chronic hepatitis, anti smooth muscle antibody, anti Factin antibody, anti LKM antibody, anti soluble liver antigen antibody
Auto immune hepatitis is associated with characteristic autoantibodies and hypergammaglobulinemia. The aim of study is to see prevalence of various types of AIH. Material and Method: Study included 66 cases of AIH, 16 cases of chronic viral hepatitis (8 hepatitis B, 8 hepatitis C) and 18 healthy control between a period of 1.5 years. Antinuclear antibody (ANA), anti-mitochondrial antibody (AMA), anti smooth muscle antibody (ASMA), anti F-actin antibody, anti parietal cell antibody were done by indirect fluorescent method (IIF) on frozen section of rat liver, stomach, and kidney. It was also done by immunodot method. ANA was repeated by ELISA technique. Result: AIH-1 formed maximum cases (89.39%) followed by AIH-2 (9.09%) and AIH-3 (1.51%). In AIH-1 23.7% and in AIH-2 66.66% were children. Male predominance was in AIH-1 (59.3%).Weakness, loss of appetite, weight loss and jaundice were common in more than 86% patients in all types of AIH. Ascitis was more common in AIH-1 (61%) than in AIH-2 (33.3%). ASMA antibody was positive in all cases of AIH-1 while anti LKM was positive in AIH-2. ANA was positive in 16.9% cases of AIH by IFT method and 30.54% by ELISA. APCA was positive in 27% cases. Two cases each of AIH-1 were positive for AMA, endomysium, anticentromere, anti Smith, anti RNP and anti-laminin antibody. All AIH-1 and AIH-2 cases had significantly elevated transaminases, bilirubin, alkaline phosphatase and serum IgG. Thus, our study concludes that AIH1 is more common than AIH2 and ASMA is more common antibody.
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