SPASMOLYTIC EFFECT OF ETHANOLIC EXTRACT OF Calotropis procera LEAVES ON In-vitro GUINEA PIG ILEUM

Authors

  • Jagadeesh K Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India
  • Shreenivas Revankar Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India
  • Jagadeesh S C Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India

DOI:

https://doi.org/10.21276/apjhs.2014.1.2.5

Keywords:

Calotropis procera, Leaves, ethanolic extract, guinea pig ileum, bioassay, spasmolytic

Abstract

Calotropis procera is widely distributed flowering plant found in India, the leaves, fruits, root and bark of the plant are known to have various medicinal properties. Guinea pig ileum is a sensitive and standard isolated tissue for evaluating the spasmodic and antispasmodic activity of organic substances. Hence guinea pig ileum was used to evaluate the spasmolytic activity of ethanolic extract of Calotropis procera. The 10ug/ml of extract inhibited the actions of histamine due to presence of calotropin like alkaloid. Thus our study showed that ethanol extract of Calotropis procera leaves produced an excellent spasmolytic effect on gastrointestinal smooth muscles (guinea pig ileum).

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Author Biographies

Jagadeesh K, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India

Department of Pharmacology, 

Shreenivas Revankar, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India

Department of Pharmacology, 

Jagadeesh S C, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India

Department of Pharmacology, 

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Published

2014-06-30

How to Cite

Jagadeesh K, Shreenivas Revankar, & Jagadeesh S C. (2014). SPASMOLYTIC EFFECT OF ETHANOLIC EXTRACT OF Calotropis procera LEAVES ON In-vitro GUINEA PIG ILEUM. Asian Pacific Journal of Health Sciences, 1(2), 65–68. https://doi.org/10.21276/apjhs.2014.1.2.5

Issue

Vol. 1 No. 2 (2014): Vol 1 No 2 (2014): | April - June 2014

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.