Formulation and in vitro evaluation of mucoadhesive microspheres of pioglitazone hydrochloride

Abstract

The work was aim to formulate and evaluate mucoadhesive microspheres of Pioglitazone Hydrochloride for treatment of diabetes type-2 by combining the potential advantages of mucoadhesion with controlled drug delivery using various ratio of polymers. Mucoadhesive microspheres were prepared by emulsion diffusion solvent evaporation technique. Microspheres were found to be discrete, spherical and free flowing. They ranged in particle size from 73-125 μm , drug release shown was 73.39-91% and mucoadhesiveness was 68-84%. Mainly in this Stirring speed affects particle size, Concentration of HPMC K100 affects drug release and concentration of Carbopol 934 affects mucoadhesiveness The microspheres exhibits good mucoadhesive property in in-vitro wash off test and showed high drug entrapment efficiency. Pioglitazone Hydrochloride release from these microspheres was slowed, extended and depended on the type of polymer used. The work has demonstrated that among all the formulations of microspheres, particularly those of formulation F8 are promising candidates for the sustained release of Pioglitazone Hydrochloride .