Synthesis and biological evaluation some new of 7-hydroxy-4-methylcoumarin derivative

Authors

  • Aniruddh Dev Singh Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, India.
  • Sushil Kumar IFTM University, Moradabad, Uttar Pradesh, India
  • Sarika Saini Smt. Tarawati Institute ofBio-Medical and Allied Sciences, Roorkee, Uttarakhand, India
  • Harsh Prabha Doon College of Education, Sunderpur, Saharanpur, Uttar Pradesh, India,

DOI:

https://doi.org/10.21276/apjhs.2017.4.4.21

Keywords:

7-hydroxy-4-methylcoumarin, acetophenones, schiff base, acetohydrazides, antimicrobial activity

Abstract

7-hydroxy-4-methylcoumarin derivatives were synthesized. The title compounds (M1-M5) were obtained by the reaction of
7-hydroxy-4-methylcoumarin with ethyl chloroacetate in the presence of potassium carbonate in acetone afforded ethyl-2-
(4-methyl-2-oxo-2H-chromen-7-yloxy)acetate, which react with hydrazine hydrate in ethanol afforded 2-(4-methyl-2-oxo2H-chromen-7-yloxy) acetohydrazide, on further reaction with various acetophenones in the presence of glacial acetic acid
in absolute alcohol gave 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N’-substituted acetohydrazides (M1-M5). The structures of
target compounds (M1-M5) were established on the basis of infrared and 1
H-nuclear magnetic resonance spectral analysis. Target
compounds (M1-M5) were screened for their antimicrobial activity and showing significant antimicrobial activity as compared
to standard drug.

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Author Biographies

Sushil Kumar, IFTM University, Moradabad, Uttar Pradesh, India

Department of Pharmaceutical Sciences, 

Sarika Saini, Smt. Tarawati Institute ofBio-Medical and Allied Sciences, Roorkee, Uttarakhand, India

Department of Pharmaceutical Sciences, 

Harsh Prabha, Doon College of Education, Sunderpur, Saharanpur, Uttar Pradesh, India,

Department of Agriculture, 

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Published

2017-12-30

How to Cite

Aniruddh Dev Singh, Sushil Kumar, Sarika Saini, & Harsh Prabha. (2017). Synthesis and biological evaluation some new of 7-hydroxy-4-methylcoumarin derivative. Asian Pacific Journal of Health Sciences, 4(4), 84–93. https://doi.org/10.21276/apjhs.2017.4.4.21