Synthesis and biological evaluation some new of 7-hydroxy-4-methylcoumarin derivative
Keywords:7-hydroxy-4-methylcoumarin, acetophenones, schiff base, acetohydrazides, antimicrobial activity
7-hydroxy-4-methylcoumarin derivatives were synthesized. The title compounds (M1-M5) were obtained by the reaction of
7-hydroxy-4-methylcoumarin with ethyl chloroacetate in the presence of potassium carbonate in acetone afforded ethyl-2-
(4-methyl-2-oxo-2H-chromen-7-yloxy)acetate, which react with hydrazine hydrate in ethanol afforded 2-(4-methyl-2-oxo2H-chromen-7-yloxy) acetohydrazide, on further reaction with various acetophenones in the presence of glacial acetic acid
in absolute alcohol gave 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N’-substituted acetohydrazides (M1-M5). The structures of
target compounds (M1-M5) were established on the basis of infrared and 1
H-nuclear magnetic resonance spectral analysis. Target
compounds (M1-M5) were screened for their antimicrobial activity and showing significant antimicrobial activity as compared
to standard drug.
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