Melanoma with unknown primary presenting as pleomorphic malignancy– Role of Immunohistochemistry in the diagnosis

Authors

  • Sandip Dukare Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India
  • Rajesh Thakur Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India
  • Vikas Narhire Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India
  • Shweta Ranka Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India
  • Priya Deshpande Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India

DOI:

https://doi.org/10.21276/apjhs.2014.1.3.29

Keywords:

Inguinal nodal metastasis, metastatic melanoma, unknown primary, Immunohistochemistry

Abstract

Melanoma with unknown primary (MUP) accounts for approximately 1% to 8% of all melanomas and was described first in 1952. We report a case of a 95 year old male with a painless, progressively increasing swelling of the inguinal region, which on investigations came out to be malignant melanoma metastatic to inguinal nodes, without clinical or radiological evidence of a known primary. Metastatic melanoma is often confused with a variety of poorly differentiated carcinomas, sarcomas, and large cell lymphomas. Immunohistochemistry along with histopathology is important in the diagnosis and sub-classification of tumors. The importance of presenting this paper is to highlight the rare presence of malignant melanoma metastatic to lymph nodes with an unknown primary, and the role of immunohistochemistry in the diagnosis.

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Author Biographies

Sandip Dukare, Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India

Assistant Professor, Department of Pathology, 

Rajesh Thakur, Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India

Residents, Department of Pathology, 

Vikas Narhire, Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India

Assistant Professor, Department of Pathology, 

Shweta Ranka, Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India

Residents, Department of Pathology, 

Priya Deshpande, Swami Ramanand Teerth Rural Government Medical College and Hospital, Ambajogai, Maharashtra, India

Residents, Department of Pathology, 

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Published

2014-09-30

How to Cite

Sandip Dukare, Rajesh Thakur, Vikas Narhire, Shweta Ranka, & Priya Deshpande. (2014). Melanoma with unknown primary presenting as pleomorphic malignancy– Role of Immunohistochemistry in the diagnosis. Asian Pacific Journal of Health Sciences, 1(3), 302–306. https://doi.org/10.21276/apjhs.2014.1.3.29