Pharmacological and biochemical assessment of Talc on Doxorubicin induced cardiac remodelling in albino Wistar rats

Abstract

Background and Objectives: Cardiac remodelling may be defined as genome expression, molecular, cellular and interstitial changes that are apparently changes in size, shape and function of the heart after cardiac injury. Type-2 diabetes is associated with significantly higher risk of heart failure (HF), coronary artery disease (CAD) and cardiac remodelling. Present study was aimed as to evaluate the Pharmacological and biochemical effects of Talc in doxorubicin induced cardiac remodelling in Wister rat. Method: Albino Wistar Rats (100-150gm) were divided into 8 groups (n=6), cardiac remodelling were induced Doxorubicin with a 2.0 mg/kg i.p. twice in a week for 20 weeks) and oral dose of talc (0.14mg/kg) for the period of 20 weeks and treated with Paracetamol for 5 day.Result and Conclusion: Exposure of Doxorubicin and Talc altered all biochemical parameter as Blood glucose, Triglyceride, CRP and Troponin-T etc. In conclusion, it was clear that talc may promotecardiac remodelling in Wistar rats.