Histopathological spectrum of meningioma and its variants

Abstract

Background: Meningiomas are tumors that arise from the lepto meningeal covering of brain and spinal cord, accounting for upto 34% of all CNS tumors. Mostly meningiomas are slow growing and are generally considered benign tumors. Meningiomas usually clinically evident in middle aged. Histopathological examination and grading of meningiomas give valuable prognostic information. Known risk factors for recurrence include histological malignancy grade, sub total resection, young age, specific sub types, brain infiltration and high proliferative rate. Aim: To study histopathological spectrum of meningiomas and its variants. Materials and methods: It is a Prospective study of 19 cases with meningiomas have been studied for a period of 1 year . Results :.Most common age group between 40-60-yrs .Male:Female -1:4. Out of 121 CNS lesions during the study period 19 cases were reported as Meningiomas which accounts for 17% of CNS lesions. Out of 19 cases, majority were benign 89.6% , Atypical 5.2% and Anaplastic 5.2% of meningiomas.Atypical meningiomas comprise between 4.7% and 7.2% of meningiomas,although using more current definition it has been reported in up to 20%. Conclusion: Continuous revision of histopathological classification systems is required to improve the diagnostic accuracy.