Ofloxacin induced steven johnson syndrome- case report

Abstract

Steven Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) is a life threatening immune complex mediated hypersensitivity reaction which mainly involves skin and mucous membrane. SJS is generally induced by the drugs. The manifestations include blisters on skin, facial swelling, and hyper pigmentation. Here, a 20 year old Indian male received 400mg of ofloxacin over 3 days period for bacterial infection and experienced a severe skin reaction which was diagnosed as toxic epidermal necrolysis. Fluoroquinolones have rarely been implicated in cases of toxic epidermal necrosis. There are few case reports of other fluoroquinolones that have been associated with toxic epidermal necrolysis. We hope that this case report create awareness to the health care professionals that ofloxacin will cause toxic epidermal necrolysis.