Hepatoprotective activity of aqueous and ethanol extracts of Feronia elephantum Correa. Stem bark and Root

Authors

  • Santosh Kumar Verma Faculty of Pharmaceutical Sciences, Motherhood University, Roorkee, Hardwar, Uttarakhand, India.
  • Rishikant Mishra Technocrats Institute of Technology Pharmacy, Bhopal, Madhya Pradesh, India
  • Mudita Mishra Faculty of Pharmaceutical Sciences, Motherhood University, Roorkee, Hardwar, Uttarakhand, India.
  • N. Balakrishnan Technocrats Institute of Technology Pharmacy, Bhopal, Madhya Pradesh, India

DOI:

https://doi.org/10.21276/apjhs.2017.4.4.28

Keywords:

Carbon tetrachloride, Feronia elephantum, hepatoprotective, LIV 52

Abstract

In the present study, the hepatoprotective activity of aqueous and ethanol extracts of Feronia elephantum Correa. (Rutaceae) stem
bark and root was evaluated against carbon tetrachloride (CCl4
)-induced hepatic damage in rats. The CCl4
(5 ml/kg)-intoxicated
rats were enhanced the serum transaminase (serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic
transaminase [SGPT]), alkaline phosphatase (ALP), total bilirubin (TB), total cholesterol (TC), while total protein (TP) level was
reduced. Treatment with aqueous and ethanol extracts of stem bark and root of F. elephantum (50 and 100 mg/kg) has brought back
the altered levels of biochemical markers of hepatic damage such as SGOT, SGPT, ALP, TB, TC, and TP to the near normal levels in
the dose-dependent manner as well as histopathological examination was carried out to evaluate hepatoprotection. The results of
this study strongly indicate that F. elephantum has a potent hepatoprotective action against CCl4
-induced hepatic damage in rats.

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Author Biographies

Santosh Kumar Verma, Faculty of Pharmaceutical Sciences, Motherhood University, Roorkee, Hardwar, Uttarakhand, India.

Department of Pharmacology,

Rishikant Mishra, Technocrats Institute of Technology Pharmacy, Bhopal, Madhya Pradesh, India

Department of Pharmacology, 

Mudita Mishra, Faculty of Pharmaceutical Sciences, Motherhood University, Roorkee, Hardwar, Uttarakhand, India.

Department of Pharmacology,

N. Balakrishnan, Technocrats Institute of Technology Pharmacy, Bhopal, Madhya Pradesh, India

Department of Pharmacology, 

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Published

2017-12-30

How to Cite

Santosh Kumar Verma, Rishikant Mishra, Mudita Mishra, & N. Balakrishnan. (2017). Hepatoprotective activity of aqueous and ethanol extracts of Feronia elephantum Correa. Stem bark and Root. Asian Pacific Journal of Health Sciences, 4(4), 119–122. https://doi.org/10.21276/apjhs.2017.4.4.28