Antileishmanial screening, physicochemical properties and drug likeness of pyrazole carbaldehyde derivatives

Authors

  • Essa Ajmi Alodeani Shaqra University, KSA
  • Mohammad Asrar Izhari Shaqra University, KSA
  • Mohammad Arshad Shaqra University, KSA

DOI:

https://doi.org/10.21276/apjhs.2015.2.2.8

Keywords:

Antileishmanial activity, synthesis and characterization, bioactivity score, physicochemical properties

Abstract

Antileishmanial activities of the five pyrazole derivatives were evaluated in vitro on a culture of Leishmania donovani promastigotes (Strain S1). The results for Antileishmanial activity were compared with the standard drug Amphotericin B. Compound three and four were found to possess good activity than the standard drug. All the compounds were characterized by various spectroscopic techniques such as IR, 1H-NMR, 13C-NMR etc. Physicochemical properties and bioactivity score studies were carried out using Lipinski’s rule of five, Molinspiration (web based software). The results of computational studies found in accordance with the results obtained experimentally.

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Author Biographies

Essa Ajmi Alodeani, Shaqra University, KSA

College of Medicine Al-Dawadmi, 

Mohammad Asrar Izhari, Shaqra University, KSA

College of Medicine Al-Dawadmi, 

Mohammad Arshad, Shaqra University, KSA

College of Medicine Al-Dawadmi,

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Published

2015-06-30

How to Cite

Essa Ajmi Alodeani, Mohammad Asrar Izhari, & Mohammad Arshad. (2015). Antileishmanial screening, physicochemical properties and drug likeness of pyrazole carbaldehyde derivatives. Asian Pacific Journal of Health Sciences, 2(2), 41–47. https://doi.org/10.21276/apjhs.2015.2.2.8

Issue

Vol. 2 No. 2 (2015): Vol 2 | Issue 2 | April - June 2015

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.