Genetic component and oral clefting – an overview

Abstract

Cleft lip and palate is a congenital defect which arises from the interplay of multiple genetic and environmental factors. Dysmorphogenesis and abnormal growth is the most exciting of the challenges we face today as we strive to understand how environmental influences interact with and cause changes in the expression of the genetic factors governing the behavior of those cells which will give rise to the entire human body, and especially the face and palatal regions. The treatment of defective genes is very much a part of the current clinical agenda dealing with craniofacial defects. The basic scientist, the dysmorphologist, the clinician, and, importantly, those with natural or acquired craniofacial defects have gained significant advantage from the critical use of available information coming from classical and experimental studies of human morphogenesis. These advantages will continue to increase as laboratory scientists and clinician scholars move rapidly together into the world of molecular and gene biology. This article highlight the overview of genes that are possibly responsile for the formation of Cleft lip with or without cleft palate.