Ischemia modified albumin, an early and novel predictor of complications of hypertension in south asian region

Abstract

Background- Hypertension is a common occurance in our society. Microalbuminuria is already evaluated in hypertension as a marker of cardiovascular risk and target organ damage. Ischemia modified albumin is a novel marker of oxidative stress. Materials and methods-84 hypertensive patients (36 without microalbuminuria and 48 with microalbuminuria) were selected for the study. 29 age and sex matched control subjects were also selected .Ischemia modified albumin was assayed in all the study subjects by albumin cobalt binding assayin semiautoanalyser. Urinary albumin creatinine ratio was also measured in all study subjects. Statistical analysis was done in graphpad software & statistical calculator software. Results: ANOVA showed Significant increase of ischemia modified albumin (p<0.005) and microalbuminuria (p<0.0001) between three groups. Furthermore student t test showed the significant increase of ischemia modified albumin in hypertensives without microalbuminuria (p<0.05) than controls. Conclusion- Ischemia modified albumin assay is a simple, rapid and cost effective test, can predict the microalbuminuria and can aware the future complications of hypertension in sufficient early stage.