Effect of Perioperative Intravenous Infusion of Lignocaine on Haemodynamic Responses to Intubation, Extubation and Post-Operative Analgesia

Abstract

Background: Intravenous bolus dose of lignocaine is generally used to reduce haemodynamic changes associated with intubation and extubation. Whereas lignocaine intravenous infusion has been used for post‑ operative analgesia. Aims and Objectives: To evaluate the effect of peri-operative intravenous infusion of lignocaine on hemodynamic
responses to intubation, extubation and post-operative analgesia. Materials and Methods:80 patients undergoing elective laparoscopic cholecystectomy were included in our study and they were randomly divided into two groups, Group A and B of 40 each. Group A patients received 6 ml normal saline as bolus over 10 minutes followed by 6 ml/hour infusion, whereas in Group B, patients received preservative free 2% lignocaine 1.5 mg/kg IV bolus (made to a volume of 6 ml with normal saline) administered over a period of 10 minutes and thereafter an infusion at a rate of 1.5 mg/kg/hour (pre‑ diluted in normal saline made to a volume of 6 ml/hour. P < 0.05 was considered as significant. Results: Group B patients showed significantly longer mean pain‑ free post‑ operative period and also a less rise in pulse rate and mean arterial pressure compared to the Group A (P < 0.05) during intubation and extubation. Conclusion: Lignocaine infusion can successfully avert the change of haemodynamics resulting from intubation and extubation.