Effect of dexmedetomidine on propofol requirement during elective spine surgery in adolescents

Authors

  • Dr. M. N. Mallika Chalmeda Anand, Rao Insitute of Medical Sciences, Karimnagar, Telangana, India.
  • Syed Ali Aasim Chalmeda Anand Rao Insitute of Medical Sciences, Karimnagar, Telangana, India
  • A. Srikanth Reddy Chalmeda Anand Rao Insitute of Medical Sciences, Karimnagar, Telangana, India

DOI:

https://doi.org/10.21276/apjhs.2017.4.4.39

Keywords:

Dexmedetomidine, intubation, propofol, spine surgery

Abstract

Background: Total intravenous anesthesia with propofol and a synthetic opioid is a frequently chosen anesthetic technique for
posterior spinal fusion. Aims and Objectives: The aim of this study is to evaluate the effect of dexmedetomidine on propofol
requirement for induction and maintenance of desired depth of anesthesia. Materials and Methods: We carried our study on
80 patients aged 20–60 years, scheduled for elective spinal surgeries under general anesthesia. The patients were divided randomly
into two Groups D and P of 40 each. Patients of Group D received an initial loading dose of dexmedetomidine at 1 µg/kg over 10 min,
started 15 min before induction of anesthesia followed by an infusion at a rate of 0.2 µg/kg/h. Patients of Group P received the same
volume of 0.9% normal saline solution as placebo. Results: Mean induction dose of propofol was found to be significantly lesser
in Group D (63.68 ± 11.368 mg) when compared with Group P (118 ± 17.042 mg). Mean maintenance dose of propofol in Group D
was 148.55 ± 42.08 mg and that in Group P was 398.24 ± 64.62 mg. The total requirement of propofol and mean requirement in
Group D (215.24 ± 43.652 mg) was lesser than the requirement in Group P (521.29 ± 71.098 mg). Conclusion: Administration of
dexmedetomidine significantly reduces the requirement of propofol while maintaining desired depth of anesthesia without any
significant complication.

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Author Biographies

Dr. M. N. Mallika, Chalmeda Anand, Rao Insitute of Medical Sciences, Karimnagar, Telangana, India.

Department of Anesthesiology, 

Syed Ali Aasim, Chalmeda Anand Rao Insitute of Medical Sciences, Karimnagar, Telangana, India

Department of Anesthesiology, 

A. Srikanth Reddy, Chalmeda Anand Rao Insitute of Medical Sciences, Karimnagar, Telangana, India

Department of Anesthesiology, 

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Published

2017-12-30

How to Cite

Dr. M. N. Mallika, Syed Ali Aasim, & A. Srikanth Reddy. (2017). Effect of dexmedetomidine on propofol requirement during elective spine surgery in adolescents. Asian Pacific Journal of Health Sciences, 4(4), 172–176. https://doi.org/10.21276/apjhs.2017.4.4.39