Stability Indicating Simultaneous Validation of Aspirin, Clopidogrel and Rosuvastatin with Forced Degradation Behavior Study by RP-HPLC in Pharmaceutical Dosage Form

Authors

  • Anurag Mishra Pacific Academy of Higher Education and Research University, Udaipur(Rajasthan), India
  • Sanjay Sharma SVKM’S, NarseeMonjee Institute of Management Studies,Mumbai-Agra Road, Shirpur-425405, India
  • Akhilesh Sharma Pacific Academy of Higher Education and Research University, Udaipur(Rajasthan), India

DOI:

https://doi.org/10.21276/apjhs.2017.4.3.45

Keywords:

HPLC, Aspirin, Clopidogrel and Rosuvastatin, Validation, Forced degradation

Abstract

For simultaneous validating anassay of Aspirin, Clopidogrel and Rosuvastatin in Capsule Dosage Form, a simple, precise and accurate RP-HPLC method has been developed. Isocratic RP-HPLC process was established on BDS hypersil C18 (250mm×4.6mm internal diameter, 5µ particle size) using mobile phase as 0.05M Potassium DihydrogenOrtho Phosphate (pH-4.0): Acetonitrile (60:40v/v) at a flow rate of 1.0 mL/min and at 235 nm the detection was carried out by using tunable absorbance detector (Waters 486). Forced degradation study was performed by acid, base and thermal degradation, as well as oxidation of the drug. The process was validated for accuracy, precision, linearity, and robustness. The method was found to be linear in the 15-45

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Author Biographies

Anurag Mishra, Pacific Academy of Higher Education and Research University, Udaipur(Rajasthan), India

Faculty of Pharmaceutical Sciences, 

Sanjay Sharma, SVKM’S, NarseeMonjee Institute of Management Studies,Mumbai-Agra Road, Shirpur-425405, India

School of Pharmacy and Technology Management, 

Akhilesh Sharma, Pacific Academy of Higher Education and Research University, Udaipur(Rajasthan), India

Faculty of Pharmaceutical Sciences, 

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Published

2017-09-30

How to Cite

Anurag Mishra, Sanjay Sharma, & Akhilesh Sharma. (2017). Stability Indicating Simultaneous Validation of Aspirin, Clopidogrel and Rosuvastatin with Forced Degradation Behavior Study by RP-HPLC in Pharmaceutical Dosage Form. Asian Pacific Journal of Health Sciences, 4(3), 306–319. https://doi.org/10.21276/apjhs.2017.4.3.45

Issue

Vol. 4 No. 3 (2017): Vol 4 | Issue 3 | July - September 2017

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.