The Use of Mannose-Binding Lectin as a Predictive Signal for Renal Decline in Non-Hypertensive Type 1 Diabetes Mellitus Males

Abstract

Introduction: Mannose-binding lectin is a macromolecule of the innate immune system that provides a third pathway of complement system activation from the protein subfamily called the collectins, it can primarily respond to pathogens that have sugar receptors on cell membranes to mediate phagocytic activity. Methods: 82 type 1 male patients were enrolled in this study as well as 21 healthy control persons, information collected from patients by questionnaire age, body mass index (BMI), duration of disease, chronic diseases, and blood collected for fasting blood sugar (FBS), hemoglobin A1C (HbA1c), serum creatinine, and mannan-binding lectin (MBL) measurements, and glomerular filtration rate was calculated using equation dependent on serum creatinine. Results: It shows a significant decrease in BMI in patients’ group as compared with control group; also, there was an increase in FBS, HbA1c, and MBL in patients’ groups as compared with control group. There was a positive correlation between MBL and BMI. Conclusion: We conclude that MBL was increased in patients with type 1 diabetes and may be an early sign of renal disease; also, there was an effect of obesity on the increase of MBL in those patients. Conclusion: The mannose-binding lectin may be used as an early diagnostic index for renal decline and the elevation of this protein is related to an increase in body weight.