Triazinone Derivatives as Antibacterial and Antimalarial Agents

Authors

  • Tarawanti Verma I.K. Gujral Punjab Technical University (IKGPTU), Jalandhar, Punjab, India
  • Manish Sinha Laureate Institute of Pharmacy, Himachal Pradesh, India
  • Nitin Bansal ASBASJSM College of Pharmacy, BELA, Ropar, Punjab, India

DOI:

https://doi.org/10.21276/apjhs.2019.6.2.1

Keywords:

Triazinone, pyrazole, antibacterial, antifungal, antimalarial, oxazolone, hydrazides

Abstract

A series of 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one derivatives (13(a-g), 18(a-g), 21(a1-a5, 21b) were synthesized using appropriate synthetic route and characterized by spectral data. Synthesized compounds were evaluated for their antimalarial and antimicrobial activities. In vitro antimalarial activity was evaluated against chloroquine-sensitive (3D-7) strains of Plasmodium falciparum by using chloroquine and quinine as standard drung. For antimicrobial activity compounds were tested against four bacteria (Escherichia coli,Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes) and three fungi(Candida albicans, Aspergillus niger, Aspergillus clavatus)using gentamicin, ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and nystatin, griseofulvin as standard drugs, respectively.

 

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Author Biographies

Tarawanti Verma, I.K. Gujral Punjab Technical University (IKGPTU), Jalandhar, Punjab, India

PhD Research scholar

Nitin Bansal, ASBASJSM College of Pharmacy, BELA, Ropar, Punjab, India

Department of Pharmacology

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Published

2019-06-30

How to Cite

Tarawanti Verma, Manish Sinha, & Nitin Bansal. (2019). Triazinone Derivatives as Antibacterial and Antimalarial Agents. Asian Pacific Journal of Health Sciences, 6(2), 1–20. https://doi.org/10.21276/apjhs.2019.6.2.1

Issue

Vol. 6 No. 2 (2019): Vol 6 | Issue 2 | April - June 2019

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.