Synthesis and Assessment of Biological Activity of Quinazolinone-4(3H)-one Derivatives as Potential Anticancer Agents
Keywords:Anticancer agents, Breast cancer, cell lines, MCF-7, Quinazolinone-4(3H)-one
One of the foremost causes of death around world is cancer. Hence, there is a continuous research going on to find newer anticancer agents with least side effect. Quinazolinone is a privileged framework with prominent anticancer activities. A sequence of eight derivatives (5a-5h) of quinazolinone-4(3H)-one was prepared and tested for activity as anticancer agents against MCF-7 cell lines in this study. One of the compounds 5e showed good activity with 63.71% inhibition of cell growth as compared to 86.96% inhibition by standard doxorubicin.
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Copyright (c) 2021 Baljeet Singh, Shailesh Sharma, Manish Sinha, S. Sagar
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