Design and development of chronomodulated pulsincap delivery system of deflazacort

Authors

  • Binu Raina Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India.
  • Pankaj sharma School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Anurag Bhargava Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Shailesh Sharma Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India
  • Abhimanyu Rai Sharma Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.4.32

Keywords:

chronothepary, Deflazacort, Rheumatoid arthritis, Pulsincap, 32 Full factorial design

Abstract

Aim of the present study was to formulate, evaluate and optimize the Pulsincap delivery system of deflazacort used in rheumatoid arthritis, based on the chronotherapeutic approach. The prepared pulsincap system consist of immediate release tablet sealed inside formaldehyde treated insoluble capsule body by hydrogel plug composed of polymer HPMC K15M and sodium alginate. Our target was to formulate a delivery system that could release the drug as per chronotherapeutic pattern of the disease (rheumatoid arthritis), so preliminary batches were prepared to study the effect of concentration of HPMC K15M and sodium alginate on the lag time of the drug release. Optimization of hydrogel plug was carried out by employing 32 full factorial design using Design expert 7 Software. The optimized batch of pulsincap sytem was found to release after a lag time of 366.66±2.887 minutes.

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Author Biography

Shailesh Sharma, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India

Department of Pharmaceutics

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Published

2018-12-30

How to Cite

Binu Raina, Pankaj sharma, Anurag Bhargava, Shailesh Sharma, & Abhimanyu Rai Sharma. (2018). Design and development of chronomodulated pulsincap delivery system of deflazacort. Asian Pacific Journal of Health Sciences, 5(4), 210–220. https://doi.org/10.21276/apjhs.2018.5.4.32

Issue

Vol. 5 No. 4 (2018): Vol 5 | Issue 4 | October - December 2018

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.

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