Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives

Authors

  • Omprakash Sharma Research Scholar, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India and Lecturer, Government Polytechnic, Mandi Adampur, Hisar, India. Mobile No- +91-9466746250, 9466869515
  • Pankaj Sharma School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Birendra Shrivastava School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Jitender Singh Lord Shiva College of Pharmacy, Sirsa, Haryana, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.4.10

Keywords:

Azole derivative, p-nitro Benzoic Acid derivative, antimicrobial activity

Abstract

This study includes the Synthesis of Azoles Based p-nitro Benzoic Acid Derivative. The compounds were prepared by reaction of p-nitro Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans).

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Author Biographies

Pankaj Sharma, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

Professor

Birendra Shrivastava, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

Director

Jitender Singh, Lord Shiva College of Pharmacy, Sirsa, Haryana, India

Professor

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Published

2018-12-30

How to Cite

Omprakash Sharma, Pankaj Sharma, Birendra Shrivastava, & Jitender Singh. (2018). Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives. Asian Pacific Journal of Health Sciences, 5(4), 54–60. https://doi.org/10.21276/apjhs.2018.5.4.10

Issue

Vol. 5 No. 4 (2018): Vol 5 | Issue 4 | October - December 2018

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.