Anti-Hypertensive Activity of Timolol Maleate Nanoparticle Loaded Transdermal Patch on Dexamethasone Induced Hypertensive Rats
The rationale of the current work was to evaluate antihypertensive activity ofTimolol maleate nanoparticles loaded transdermal patch. Nanoparticles loaded transdermal patch of timolol maleate was prepared using Compritol 888, Lutrol F68, tween 80 etc. The formulated patches were subjected to skin irritation study and in–vivo antihypertensive activity. Hypertension was induced by dexamethasone in experimental rats. No any marked skin irritation observed before and after applying the patch. Both systolic and diastolic blood pressure in experimental animals was reduced significantly after 7 days treatment with Timolol maleate nanoparticles loaded transdermal patch. So, it was concluded that timolol maleate patch could be formulated into a matrix-type naoparticle loaded transdermal patch for the management of hypertension. Also, this study can be considered as a new report that focuses on the problem of the side-effects associated with the modern medicaments toward hypertension
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