Anti-Hypertensive Activity of Timolol Maleate Nanoparticle Loaded Transdermal Patch on Dexamethasone Induced Hypertensive Rats

Authors

  • Birendra Shrivastava School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Parveen Kumar 1 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India2 Shri Ram college of Pharmacy, Karnal, Haryana, India
  • Madan Mohan Gupta 1 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India2 School of Pharmacy, Faculty of MedicalSciences, The University of The West Indies, Trinidad & Tobago, West Indies
  • Anil Kumar Sharma Shri Ram college of Pharmacy, Karnal, Haryana, India

DOI:

https://doi.org/10.21276/apjhs.2019.6.2.21

Abstract

The rationale of the current work was to evaluate antihypertensive activity ofTimolol maleate nanoparticles loaded transdermal patch. Nanoparticles loaded transdermal patch of timolol maleate was prepared using Compritol 888, Lutrol F68, tween 80 etc. The formulated patches were subjected to skin irritation study and in–vivo antihypertensive activity. Hypertension was induced by dexamethasone in experimental rats. No any marked skin irritation observed before and after applying the patch. Both systolic and diastolic blood pressure in experimental animals was reduced significantly after 7 days treatment with Timolol maleate nanoparticles loaded transdermal patch. So, it was concluded that timolol maleate patch could be formulated into a matrix-type naoparticle loaded transdermal patch for the management of hypertension. Also, this study can be considered as a new report that focuses on the problem of the side-effects associated with the modern medicaments toward hypertension

Keywords: , , .

Downloads

Download data is not yet available.

Author Biography

Madan Mohan Gupta, 1 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India2 School of Pharmacy, Faculty of MedicalSciences, The University of The West Indies, Trinidad & Tobago, West Indies

Laboratory of Pharmaceutical Formulation Design and Development


Downloads

Published

2019-06-30

How to Cite

Birendra Shrivastava, Parveen Kumar, Madan Mohan Gupta, & Anil Kumar Sharma. (2019). Anti-Hypertensive Activity of Timolol Maleate Nanoparticle Loaded Transdermal Patch on Dexamethasone Induced Hypertensive Rats. Asian Pacific Journal of Health Sciences, 6(2), 145–151. https://doi.org/10.21276/apjhs.2019.6.2.21

Issue

Vol. 6 No. 2 (2019): Vol 6 | Issue 2 | April - June 2019

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.