Synthesis, Characterization and Antimicrobial evaluation of novel Azole Based (p-Toluic Acid) derivatives

Authors

  • Omprakash Sharma School of Pharmaceutical Sciences,Jaipur National University, Jaipur, Rajasthan, India and , Government Polytechnic,Mandi Adampur, Hisar, India
  • Pankaj Sharma Jaipur National University, Jaipur, Rajasthan, India
  • Birendra Shrivastava Jaipur National University, Jaipur, Rajasthan, India
  • Jitender Singh Lord Shiva College of Pharmacy, Sirsa, Haryana, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.3.46

Keywords:

Azole derivative, p-Toluic Acid derivative, antimicrobial activity

Abstract

This study includes the Synthesis of Azoles Based p-Toluic Acid Derivative. The compounds were prepared by reaction of p-Toluic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4- thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans).

Downloads

Download data is not yet available.

Author Biographies

Omprakash Sharma, School of Pharmaceutical Sciences,Jaipur National University, Jaipur, Rajasthan, India and , Government Polytechnic,Mandi Adampur, Hisar, India

Research Scholar, Lecturer

Pankaj Sharma, Jaipur National University, Jaipur, Rajasthan, India

Professor, School of Pharmaceutical Sciences

Birendra Shrivastava, Jaipur National University, Jaipur, Rajasthan, India

Director, School of Pharmaceutical Sciences

Jitender Singh, Lord Shiva College of Pharmacy, Sirsa, Haryana, India

Professor

Downloads

Published

2018-09-30

How to Cite

Omprakash Sharma, Pankaj Sharma, Birendra Shrivastava, & Jitender Singh. (2018). Synthesis, Characterization and Antimicrobial evaluation of novel Azole Based (p-Toluic Acid) derivatives. Asian Pacific Journal of Health Sciences, 5(3), 325–330. https://doi.org/10.21276/apjhs.2018.5.3.46

Issue

Vol. 5 No. 3 (2018): Vol 5 | Issue 3 | July - September 2018

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.