Synthesis, Characterization and Antimicrobial evaluation of novel Azole Based (p-Toluic Acid) derivatives
Keywords:Azole derivative, p-Toluic Acid derivative, antimicrobial activity
This study includes the Synthesis of Azoles Based p-Toluic Acid Derivative. The compounds were prepared by reaction of p-Toluic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4- thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans).
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