Transdermal Patch of Timolol Maleate: Formulation and Evaluation

Abstract

Transdermal drug delivery system can be described as desecrate and independent type of dosage form deliver the drug by controlled manner when applied to skin. Patches of Timolol Maleate was prepared by solvent casting technique. Timolol maleate is an antihypertensive drug having λmax 294 nm. Solid lipid nanoparticles (SLN) of Timolol maleate was prepared using microwave assisted microencapsulation technique by using stearic acid, tween 20 and PEG 400. Transdermal patches were prepared using different grades of HPMC i.e. HPMC K4M, HPMC K15M, HPMC 50 cps HPMC K100M and cellulose acetate and different percentage of glycerine. Final formulation prepared by HPMC 50 cps. Drug diffusion study performed by using modified KesharyChien Diffusion Cell. Rat skin used as membrane for diffusion. Prepared patches examined for skin irritation and antihypertensive study. Anti- hypertensive activity performed by using BioPack instrument for blood pressure measurement. Stability studies performed at 40°C/75% RH, and 25°C/60% RH conditions. The physical stability of Timolol Maleate based transdermal patches proved unchanged after storage up to 3 months. Final prepared patch having good tensile strength, folding endurance, weight variation and drug diffusion as 91.75% in a period of 24 hrs.