Design and development of immediate release tablets of terbutaline sulfate using 32 full factorial statistical design
Keywords:Ac-Di-Sol, Asthma, immediate release tablet, sodium starch glycolate, terbutaline sulfate
Aim: Present study was aimed at developing an immediate release tablets (IRT) of Terbutaline sulphate (TS) that can be used forquick relief from asthma attacks.
Method: IRT’s were formulated using Ac-Di-Sol and Sodium starch glycolate as superdisintegrants. There concentrations were optimized using a 32 full-factorial design to produce tablets able to disintegrate within 30 s with minimum friability. Then the tablets were evaluated for physical evaluation and drug release studies.
Results: The optimizedIRT formulation (OIRT1) showed a disintegration time of 31.67 ± 0.577 s and friability value of 0.58 ± 0.021 %. The accelerated stability studies showed no significant changes in physicochemical properties and release behaviour.
Conclusions: It can be concluded from the study that the IRT of TS can be successfully formulated to get a fast release and these tablets can be used to get quick relief from asthma attacks.
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