Chronobiology and Chronotherapy for rheumatoid arhthritis
Keywords:Pulsatile, circardian, delivery, drug
Pulsatile drug delivery systems have been a major field of research recently. It is the most interesting time-specific and site-specific system. This system is designed for chronopharmacotherapy which is based on circadian rhythm. This means these systems will deliver drug at the time when disease displays it's most morbid and mortal state within a circadian cycle. The use of these systems has been investigated on diseases like asthma, arthritis, ulcers, cardiovascular diseases, hypercholesterolemia, cancer etc. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes are discussed in the article below.
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